May 4, 2011Cardiovascular ResearchOpen Access

Control of sympathetic vasomotor tone by catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata

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Population

Anaesthetized rats in vivo and perfused rat working heart brainstem preparations in situ

Design

Preclinical

Authors

NMN MarinaFrenchay Hospital AAAna P. AbdalaUniversity of Bristol AKAlla KorsakInstitut des Sciences Cognitives Marc Jeannerod

Discussion

Member takes

Implication

C1 neurons sustain basal sympathetic tone and BP in animals; leaves open selective targeting in human hypertension.

Structured PICO

Population

Anaesthetized rats in vivo and perfused rat working heart brainstem preparations in situ

Intervention

Acute silencing of C1 neurones by application of the insect peptide allatostatin following cell-specific targeting with a lentiviral vector to express the inhibitory Drosophila allatostatin receptor

Outcome

Renal sympathetic nerve activity, arterial blood pressure, and hypercapnia-evoked sympathetic and cardiovascular responsessurrogate

Medullary catecholaminergic C1 neurones play a fundamental role in maintaining resting sympathetic vasomotor tone and arterial blood pressure, but do not mediate sympathoexcitation evoked by central actions of CO2.

Cite This Study

Marina et al. (2011) studied this question.

synapsesocial.com/papers/6a8544870940f46f59d985ed https://doi.org/10.1093/cvr/cvr128

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Control of sympathetic vasomotor tone by catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Control of sympathetic vasomotor tone by catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider