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February 9, 2018ESC Heart FailureOpen Access

Acute Heart Failure Following Myocardial Infarction: Complement Activation Correlates with the Severity of Heart Failure in Patients Developing Cardiogenic Shock

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Why the study?

Does the degree of complement activation correlate with the severity of heart failure and cardiogenic shock in patients following acute ST-elevation myocardial infarction?

Population

61 patients developing heart failure within 48 hours after percutaneous coronary intervention-treated…

Design

Cohort

Follow-up

42 days

Authors

HOHilde L. OrremPNPer H. NilssonSPSøren Erik Pischke

Discussion

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Overview

Hypothesis-generating; supports targeted complement studies in post-MI cardiogenic shock but should not yet alter practice.

Structured PICO

Does the degree of complement activation correlate with the severity of heart failure and cardiogenic shock in patients following acute ST-elevation myocardial infarction?

P
Population
61 patients developing heart failure within 48 hours after percutaneous coronary intervention-treated ST-elevation myocardial infarction (9 with cardiogenic shock, 52 without shock) and 44 age- and sex-matched healthy controls.
C
Comparator
Non-shock group (n=52) and healthy controls (n=44)
O
Outcome
Levels of complement activation products (C4bc, C3bc, C3bBbP, and sC5b-9) and their correlation with regional myocardial contractility (wall motion score index) from inclusion to day 42.surrogate

Complement activation products are significantly elevated in patients with cardiogenic shock following STEMI and correlate with impaired regional myocardial contractility, suggesting a potential pathogenic role.

Cite This Study

Orrem et al. (2018) studied this question.

synapsesocial.com/papers/6a77decfa7498e5110aef013https://doi.org/10.1002/ehf2.12266
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