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October 1, 2012Current Vascular Pharmacology

Antihypertensive Efficacy and Tolerability of Aliskiren/Amlodipine Single- Pill Combinations in Patients with an Inadequate Response to Aliskiren Monotherapy

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Why the study?

Does aliskiren/amlodipine single-pill combination improve blood pressure reduction in patients with mild-to-moderate hypertension non-responsive to aliskiren monotherapy?

Population

Patients with mild-to-moderate hypertension who were non-responsive to aliskiren monotherapy.

Comparison

Once-daily aliskiren/amlodipine 300/10 mg or… vs Once-daily aliskiren 300 mg monotherapy for 8…

Design

RCT, randomized, double-blind

Follow-up

8 weeks

Authors

NGNicola GloriosoMTMathew ThomasCTChiara Troffa

Discussion

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Overview

Aliskiren/amlodipine SPCs offer effective step-up therapy for aliskiren non-responders; extends RCT evidence for dual therapy in hypertension.

Structured PICO

Does aliskiren/amlodipine single-pill combination improve blood pressure reduction in patients with mild-to-moderate hypertension non-responsive to aliskiren monotherapy?

P
Population
Patients with mild-to-moderate hypertension who were non-responsive to aliskiren monotherapy (mean sitting diastolic BP ≥ 90 and < 110 mmHg after a 4-week run-in with aliskiren 300 mg).
I
Intervention
Once-daily aliskiren/amlodipine 300/10 mg or 300/5 mg single-pill combinations for 8 weeks.
C
Comparator
Once-daily aliskiren 300 mg monotherapy for 8 weeks.
O
Outcome
Mean reductions in mean sitting systolic BP/mean sitting diastolic BP at week 8 endpoint.surrogate

Aliskiren/amlodipine single-pill combinations offer an effective step-up therapy for patients with hypertension inadequately controlled on aliskiren monotherapy.

Cite This Study

Glorioso et al. (2012) studied this question.

synapsesocial.com/papers/6a77e2dbcb17b32ad6bd8636https://doi.org/10.2174/157016112803520765
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Treatment with aliskiren/amlodipine combination in patients with moderate-to-severe hypertension: a randomised, double-blind, active comparator trial2012 · 5 citations
  2. 2Efficacy of aliskiren/hydrochlorothiazide single-pill combinations in aliskiren non-responders2008 · 30 citations
  3. 3Comparative Efficacy and Safety of Combination Aliskiren/Amlodipine and Amlodipine Monotherapy in African Americans With Stage 2 Hypertension2011 · 23 citations
  4. 4Long-term safety, tolerability and efficacy of combination therapy with aliskiren and amlodipine in patients with hypertension2009 · 66 citations
  5. 5Antihypertensive Efficacy of the Oral Direct Renin Inhibitor Aliskiren as Add‐On Therapy in Patients Not Responding to Amlodipine Monotherapy2007 · 97 citations