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August 17, 2012International Journal of Clinical Practice

Treatment with aliskiren/amlodipine combination in patients with moderate-to-severe hypertension: a randomised, double-blind, active comparator trial

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Why the study?

Does aliskiren/amlodipine combination therapy reduce blood pressure in patients with moderate-to-severe hypertension compared with amlodipine monotherapy?

Population

n=485 patients with moderate-to-severe hypertension (mean sitting systolic blood pressure ≥ 160 to < 200 mmHg)

Comparison

Aliskiren/amlodipine combination therapy vs Amlodipine monotherapy

Design

RCT, randomised, double-blind

Follow-up

8 weeks

Authors

RBRuediger C. Braun‐DullaeusSSS. B. ShustovCACindy Alvarez

Discussion

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Overview

Supports aliskiren/amlodipine combination as initial therapy for moderate-to-severe hypertension; extends monotherapy comparisons with direct RCT evidence.

Structured PICO

Does aliskiren/amlodipine combination therapy reduce blood pressure in patients with moderate-to-severe hypertension compared with amlodipine monotherapy?

P
Population
n=485 patients with moderate-to-severe hypertension (mean sitting systolic blood pressure ≥ 160 to < 200 mmHg)
I
Intervention
Aliskiren/amlodipine combination therapy (150/5 mg once-daily for 1 week, up-titrated to 300/10 mg for 7 weeks)
C
Comparator
Amlodipine monotherapy (5 mg once-daily for 1 week, up-titrated to 10 mg for 7 weeks)
O
Outcome
Change from baseline to week 8 endpoint in mean sitting systolic blood pressure (msSBP)surrogate

Aliskiren/amlodipine combination therapy provides significantly greater blood pressure reductions and higher control rates than amlodipine monotherapy in patients with moderate-to-severe hypertension.

Cite This Study

Braun‐Dullaeus et al. (2012) studied this question.

synapsesocial.com/papers/6a7ee1356e4b721fcdc2fd61https://doi.org/10.1111/j.1742-1241.2012.02967.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-term safety, tolerability and efficacy of combination therapy with aliskiren and amlodipine in patients with hypertension2009 · 66 citations
  2. 2Comparative Efficacy and Safety of Combination Aliskiren/Amlodipine and Amlodipine Monotherapy in African Americans With Stage 2 Hypertension2011 · 23 citations
  3. 3Aliskiren and Amlodipine in the Management of Essential Hypertension: Meta-Analysis of Randomized Controlled Trials2013 · 13 citations
  4. 4Antihypertensive Efficacy and Tolerability of Aliskiren/Amlodipine Single- Pill Combinations in Patients with an Inadequate Response to Aliskiren Monotherapy&amp;yen;2012 · 10 citations
  5. 5Antihypertensive Efficacy of the Oral Direct Renin Inhibitor Aliskiren as Add‐On Therapy in Patients Not Responding to Amlodipine Monotherapy2007 · 97 citations