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February 1, 1999HeartOpen Access

Disparity between studies of the stability of BNP in blood: comparison of endogenous and exogenous peptide

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Why the study?

Is endogenous BNP stable in whole blood at room temperature for three days?

Population

Mixed population including patients with left ventricular systolic dysfunction (LVSD) and healthy volunteers

Design

Other

Follow-up

3 days (storage duration)

Authors

DMDavid MurdochThe University of QueenslandJBJohn ByrneNHS Greater Glasgow and ClydeRFRosemary FarmerOhio Department of Agriculture

Discussion

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Overview

Supports simplified BNP handling in HF diagnostics; confirms prior stability data but leaves open prospective validation.

Structured PICO

Is endogenous BNP stable in whole blood at room temperature for three days?

P
Population
Mixed population including patients with left ventricular systolic dysfunction (LVSD) and healthy volunteers
I
Intervention
Storage of whole blood at room temperature for three days to assess brain natriuretic peptide (BNP) stability
O
Outcome
Stability of endogenous versus exogenous brain natriuretic peptide (BNP) in whole bloodsurrogate

Endogenous BNP is stable in whole blood at room temperature for three days, which simplifies sample handling for diagnostic use in heart failure.

Cite This Study

Murdoch et al. (1999) studied this question.

synapsesocial.com/papers/6a77fa08f6b553d308aee57fhttps://doi.org/10.1136/hrt.81.2.212
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Brain natriuretic peptide is stable in whole blood and can be measured using a simple rapid assay: implications for clinical practice1997 · 83 citations
  2. 2Assessment of heart failure with plasma natriuretic peptides1998 · 1 citations
  3. 3Stabilization of human brain natriuretic peptide in blood samples1994 · 37 citations