Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 11, 2000Clinical Chemistry and Laboratory Medicine (CCLM)

Stability of Brain Natriuretic Peptide (BNP) in Human Whole Blood and Plasma

View Full Paper
Ask AI
Bookmark
Share

Key result

Brain natriuretic peptide is stable at room temperature for 24 hours or up to 30°C for 12 hours, and aprotinin prevents degradation in samples preserved >1 month at -20°C.

Population

Human whole blood and plasma samples

Design

Other

Authors

AGAgnès Gobinet-GeorgesCentre Hospitalier Universitaire de BordeauxNVNathalie ValliPolyclinique de Bordeaux-TonduHFHélène Filliatre

Discussion

Loading...

Member takes

Overview

May simplify BNP sample handling in HF labs; leaves open assay-specific validation in larger cohorts.

Structured PICO

P
Population
Human whole blood and plasma samples
E
Exposure
Different handling conditions (sample collection, storage temperatures, freezing temperatures, presence/absence of aprotinin)
O
Outcome
Stability of brain natriuretic peptide (BNP)surrogate

BNP samples can be safely stored at room temperature for up to 24 hours before freezing, simplifying sample handling for heart failure screening.

Cite This Study

Gobinet-Georges et al. (2000) studied Heart failure. Different handling conditions (sample collection, storage temperatures, freezing temperatures) was evaluated on Stability of brain natriuretic peptide. Brain natriuretic peptide is stable at room temperature for 24 hours or up to 30°C for 12 hours, and aprotinin prevents degradation in samples preserved >1 month at -20°C.

synapsesocial.com/papers/6a9fcc2a4b4a72036190deddhttps://doi.org/10.1515/cclm.2000.076
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Brain natriuretic peptide is stable in whole blood and can be measured using a simple rapid assay: implications for clinical practice1997 · 83 citations
  2. 2Disparity between studies of the stability of BNP in blood: comparison of endogenous and exogenous peptide1999 · 14 citations
  3. 3Plasma Brain Natriuretic Peptide as an Indicator of Left Ventricular Systolic Function and Long-term Survival After Acute Myocardial Infarction1996 · 702 citations
  4. 4Stabilization of human brain natriuretic peptide in blood samples1994 · 37 citations
  5. 5Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide.1991 · 1,363 citations