September 1, 1998Clinical Science
Prolonged stability of brain natriuretic peptide: importance for non-invasive assessment of cardiac function in clinical practice
Why the study?
Are BNP and ANP stable in blood samples left at room temperature for up to 2 days?
Population
8 heart transplant recipients
Comparison
Blood samples left at room temperature for 2… vs Blood processed immediately (initial)
Design
Other
Follow-up
2 days
Authors
Discussion
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Member takes
Implication
May support delayed BNP processing in labs; leaves open prospective validation across assays and settings.
Structured PICO
Are BNP and ANP stable in blood samples left at room temperature for up to 2 days?
P
Population
8 heart transplant recipients
I
Intervention
Blood samples left at room temperature for 2 hours or 2 days
C
Comparator
Blood processed immediately (initial)
O
Outcome
Stability of BNP and ANP levelssurrogate
BNP is stable at room temperature for up to 2 days, making it a practical biomarker for routine clinical and community screening, unlike ANP which degrades significantly.
Cite This Study
Buckley et al. (1998) studied this question.