What question did this study set out to answer?

To determine whether the intermediate filament system is disrupted alongside myofibrillar disorganization during delayed onset muscle soreness in humans.

February 1, 1984International Journal of Sports Medicine

Delayed Muscle Soreness and Cytoskeletal Alterations: An Immunocytological Study in Man

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To determine whether the intermediate filament system is disrupted alongside myofibrillar disorganization during delayed onset muscle soreness in humans.
Obtained muscle biopsies from the right vastus lateralis of six males (aged 23 ± 3 years) presenting with severe post-exercise thigh soreness.
Visualized intermediate filament organization 3 days post-exercise using indirect immunofluorescence microscopy with a desmin-specific antibody.
Observed extensive longitudinal desmin extensions across muscle biopsies obtained 3 days following exercise.
Identified prominent autofluorescent granules beneath the sarcolemma, pointing to elevated lysosomal degradation accompanying the cytoskeletal and myofibrillar disturbances.

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Implication

Biopsy study demonstrates desmin filament disruption in exercised males, indicating that delayed muscle soreness involves cytoskeletal damage and lysosomal activation.

Cite This Study

Fridén et al. (1984) studied this question.

synapsesocial.com/papers/6a782bc2576efb0ddaf7ec03 https://doi.org/10.1055/s-2008-1025873

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Implication

Biopsy study demonstrates desmin filament disruption in exercised males, indicating that delayed muscle soreness involves cytoskeletal damage and lysosomal activation.

Delayed Muscle Soreness and Cytoskeletal Alterations: An Immunocytological Study in Man

Key Points

Discussion

Implication

Cite This Study

Delayed Muscle Soreness and Cytoskeletal Alterations: An Immunocytological Study in Man

Key Points

Discussion

Implication

Cite This Study

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