Why the study?
An impaired nocturnal decrease in diastolic blood pressure increases blood pressure load and contributes to endothelial dysfunction, but its relationship with oxidative stress markers remains to be clarified.
Is a non-dipper diastolic blood pressure profile associated with increased oxidative stress in patients with essential hypertension?
Observational (n=248)
Is a non-dipper diastolic blood pressure profile associated with increased oxidative stress in patients with essential hypertension?
An impaired nocturnal decrease in diastolic blood pressure in hypertensive patients is associated with abnormalities in redox status, specifically an increased TBARS/Thiol ratio and higher serum copper levels.
Oxidative stress markers may differ by nocturnal DBP dipping status in hypertension; leaves open causal role or therapeutic targeting.
An impaired nocturnal decrease in diastolic blood pressure (DBP) increases the blood pressure (BP) load, which is a main factor in endothelial dysfunction, atherosclerosis, and arterial stiffness. We aimed to quantify some markers of oxidative stress in hypertensive patients, to compare their levels between individuals with dipper and non-dipper DBP profiles, and to assess their correlation with the nocturnal DBP (nDBP) dipping. It was an observational study that included patients older than 18 years with a diagnosis of essential hypertension who consented to participate. The collected variables were some indices of 24-h ambulatory blood pressure monitoring, demographic, epidemiological, clinical, and laboratory variables. Plasma thiobarbituric acid reactive substances (TBARS) and reduced thiols, together with serum vitamin E, vitamin A, copper (Cu), and zinc (Zn) levels were assessed as oxidative stress markers. We recruited 248 patients with a median age of 56 years (56% women). The percentage of nDBP dipping showed a weak positive correlation with reduced thiol, vitamin E, and vitamin A levels; and a weak negative correlation with Cu levels. We also found a negative correlation between nDBP dipping and the TBARS/Thiol, TBARS/Vitamin E, and TBARS/Vitamin A ratios. After multivariate analysis, we found that increased TBARS/Thiol ratio and serum Cu levels were associated with a higher risk of a non-dipper DBP profile. As in other situations of increased cardiovascular risk, an impaired nDBP decrease may coincide with abnormalities in redox status.
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Vázquez-Agra et al. (2022) conducted an observational in essential hypertension (n=248). Non-dipper diastolic blood pressure profile vs. Dipper diastolic blood pressure profile was evaluated on Oxidative stress markers (including TBARS/Thiol ratio and serum Cu levels).
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