Key result
Midodrine administration in individuals with high-level spinal cord injury significantly improved posterior cerebral artery blood velocity responses during orthostatic stress and increased orthostatic tolerance by 59%.
Why the study?
Does midodrine improve cerebral blood flow responses and orthostatic tolerance during orthostatic stress in individuals with high-level spinal cord injury?
Population
10 individuals with spinal cord injury >T6, and 10 age- and sex-matched able-bodied controls
Comparison
10 mg midodrine administered prior to… vs Pre-midodrine baseline in the SCI group, and…
Design
Other
Follow-up
Acute (during progressive tilt-test)
Authors
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May aid orthostatic tolerance in high-level SCI; hypothesis-generating and requires randomized confirmation before practice change.
Does midodrine improve cerebral blood flow responses and orthostatic tolerance during orthostatic stress in individuals with high-level spinal cord injury?
Absolute Event Rate: 4% vs 10%
p-value: p=<0.05
Midodrine improves posterior cerebral artery blood velocity and orthostatic tolerance during orthostatic stress in individuals with high-level spinal cord injury.
Phillips et al. (2014) studied High-level spinal cord injury (SCI) (n=20). Midodrine vs. Baseline (no midodrine) was evaluated on Decline in posterior cerebral artery blood velocity (PCAv) 30-60 seconds following tilt (p=<0.05). Midodrine administration in individuals with high-level spinal cord injury significantly improved posterior cerebral artery blood velocity responses during orthostatic stress and increased orthostatic tolerance by 59%.
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