Key result
Administration of 10 mg midodrine in individuals with high-level spinal cord injury improved neurovascular coupling by 70% and cognitive function by 13% (P<0.05).
Why the study?
Does midodrine improve neurovascular coupling and cognitive function in individuals with low blood pressure secondary to high-level spinal cord injury?
Population
10 individuals with high-level spinal cord injury and 10 age- and sex-matched controls
Comparison
Midodrine 10 mg (alpha1-agonist) vs Baseline (pre-midodrine) and healthy controls
Design
Case-control
Authors
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May support midodrine for cognitive issues in high-level spinal cord injury; hypothesis-generating and requires randomized confirmation.
Does midodrine improve neurovascular coupling and cognitive function in individuals with low blood pressure secondary to high-level spinal cord injury?
p-value: p=<0.05
Increasing blood pressure with midodrine in patients with high-level spinal cord injury improves neurovascular coupling and cognitive performance.
Phillips et al. (2014) studied High-level spinal cord injury (n=20). Midodrine hydrochloride vs. Baseline (pre-midodrine) and healthy controls was evaluated on Neurovascular coupling and cognitive function (p=<0.05). Administration of 10 mg midodrine in individuals with high-level spinal cord injury improved neurovascular coupling by 70% and cognitive function by 13% (P<0.05).
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