Change in Circulating Adiponectin in Advanced Old Age: Determinants and Impact on Physical Function and Mortality. The Cardiovascular Health Study All Stars Study
Key result
High adiponectin levels (≥20 mg/L) and longitudinal increases in adiponectin independently predicted all-cause mortality in older adults (HR 1.85; 95% CI 1.36-2.52 and HR 1.30; 95% CI 1.10-1.52).
Why the study?
Are longitudinal changes in adiponectin levels associated with physical decline and mortality in older adults?
Population
988 older adults in a population-based study who completed examinations in 1996-1997 and 2005-2006, and had…
Design
Cohort
Follow-up
Follow-up through June 2009
Authors
Discussion
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Member takes
Implication
May signal higher mortality risk in older adults; leaves open whether adiponectin is a causal biomarker or intervention target.
Study Design
Type
Cohort (n=988)
Structured PICO
Are longitudinal changes in adiponectin levels associated with physical decline and mortality in older adults?
P
Population
988 older adults from a population-based study with serial adiponectin measurements between 1996-1997 and 2005-2006, followed through June 2009.
O
Outcome
Physical deterioration and all-cause mortalityhard clinical
Main Result
Hazard Ratio: 1.85 (95% CI 1.36–2.52)
In older adults, adiponectin levels increase over time, and higher levels or greater increases are independently associated with physical disability and increased mortality.
Limitations
- Cannot determine whether adiponectin is a marker or causal factor for mortality
Cite This Study
Kizer et al. (2010) conducted a cohort in Advanced old age (n=988). Adiponectin levels and longitudinal change vs. Lower adiponectin levels / no change was evaluated on All-cause mortality (HR 1.85, 95% CI 1.36-2.52). High adiponectin levels (≥20 mg/L) and longitudinal increases in adiponectin independently predicted all-cause mortality in older adults (HR 1.85; 95% CI 1.36-2.52 and HR 1.30; 95% CI 1.10-1.52).