Key result
High adiponectin levels in older men were associated with increased all-cause mortality in those free of CVD (RR 1.55; 95% CI 1.19-2.02) and those with heart failure, but not in those with CVD alone.
Why the study?
Are high circulating adiponectin levels associated with increased mortality in older men with and without cardiovascular disease and heart failure?
Population
4046 men aged 60 to 79 years drawn from general practices in 24 British towns, stratified by presence of…
Comparison
High circulating adiponectin levels (top third) vs Low circulating adiponectin levels (bottom third)
Design
Cohort
Follow-up
mean 6 years
Authors
Loading...
High adiponectin should not yet inform clinical decisions in older men; leaves open its value as a biomarker in those without CVD or with HF.
Cohort (n=4,046)
Yes
Are high circulating adiponectin levels associated with increased mortality in older men with and without cardiovascular disease and heart failure?
Relative Risk: 1.55 (95% CI 1.19–2.02)
p-value: p=.002 for trend
In older men, high adiponectin levels are paradoxically associated with increased all-cause and CVD mortality in those with heart failure and those free of CVD.
S. Goya Wannamethee (2007) conducted a cohort in older men with and without diagnosed cardiovascular disease (CVD) and heart failure (n=4,046). High adiponectin levels (top third) vs. Low adiponectin levels (bottom third) was evaluated on all-cause mortality in men with no diagnosed CVD or heart failure (RR 1.55, 95% CI 1.19-2.02, p=.002 for trend). High adiponectin levels in older men were associated with increased all-cause mortality in those free of CVD (RR 1.55; 95% CI 1.19-2.02) and those with heart failure, but not in those with CVD alone.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: