Key result
Visceral fat area was independently and positively associated with arterial stiffness, measured by brachial-ankle pulse wave velocity, in patients with HFpEF (P=0.024).
Why the study?
Heart failure and preserved ejection fraction is often complicated by abdominal obesity and arteriosclerosis, but the relationship between adipose tissue distribution and arterial stiffness in HFpEF needed to be determined.
Cross-Sectional (n=93)
p-value: p=0.024
In patients with HFpEF, visceral fat area is independently associated with increased arterial stiffness, suggesting a link between abdominal obesity and vascular dysfunction in this population.
May link central adiposity to arterial stiffness in HFpEF; hypothesis-generating, should not yet change practice.
OBJECTIVES: Heart failure and preserved ejection fraction (HFpEF) in patients is often complicated by abdominal obesity and arteriosclerosis. The aim of this study was to determine the relationship between adipose tissue distribution and arterial stiffness in patients with HFpEF. METHODS: This was a cross-sectional descriptive study involving 93 patients with HFpEF. Several anthropometric measurements were measured, including height, weight, waist circumference, body fat mass, percent body fat, body fat rate, and visceral fat area (VFA). We calculated body mass index. Arterial stiffness was assessed by measurement of brachial-ankle pulse wave velocity (baPWV). The association between VFA and baPWV was investigated by linear regression analysis. RESULTS: In univariate analysis, VFA showed strong relations with bilateral baPWV in Spearman correlation analysis (P = 0.003 and P = 0.002, respectively). After adjusting for VFA, age, systolic blood pressure, diastolic blood pressure, and heart rate, VFA and age were significantly and positively associated with bilateral baPWV (P = 0.024 and P = 0.032, respectively). After adjusting for VFA, age, left ventricular posterior wall, and interventricular septal thickness, VFA and age were still significantly correlated with bilateral baPWV (P = 0.028 and P = 0.008, respectively). CONCLUSIONS: In patients with HFpEF, adipose tissue distribution was correlated with arterial stiffness. VFA was independently associated with baPWV.
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Hu et al. (2022) conducted a cross-sectional in Heart failure and preserved ejection fraction (HFpEF) (n=93). Visceral fat area (VFA) was evaluated on Arterial stiffness assessed by brachial-ankle pulse wave velocity (baPWV) (p=0.024). Visceral fat area was independently and positively associated with arterial stiffness, measured by brachial-ankle pulse wave velocity, in patients with HFpEF (P=0.024).
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