Why the study?
Does enalapril compared to amiloride improve blood pressure reduction in patients with uncontrolled hypertension receiving hydrochlorothiazide?
Population
82 patients with uncontrolled blood pressure receiving hydrochlorothiazide 25 mg daily
Comparison
Enalapril 10-20 mg/day, with dose doubled in the… vs Amiloride 2.5-5 mg/day, with dose doubled in the…
Design
RCT, randomized, double-blind
Follow-up
12 weeks
Authors
Loading...
Enalapril should be preferred over amiloride as add-on to hydrochlorothiazide; extends direct RCT evidence for ACEI in uncontrolled hypertension.
Does enalapril compared to amiloride improve blood pressure reduction in patients with uncontrolled hypertension receiving hydrochlorothiazide?
Enalapril is more effective than amiloride as an add-on therapy for lowering blood pressure in patients with uncontrolled hypertension on hydrochlorothiazide.
Guerrero et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: