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September 18, 2001Circulation

Increased Prevalence of Autoimmune Phenomena and Greater Risk for Alloreactivity in Female Heart Transplant Recipients

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Why the study?

Does female sex influence alloreactivity, acute rejection, transplant-related coronary artery disease, and survival in primary cardiac allograft recipients?

Population

520 consecutive recipients of a primary cardiac allograft between 1992 and 2000 at a single center

Comparison

Female sex vs Male sex

Design

Cohort

Authors

KLKatherine LietzRJRanjit JohnAKAlfred Kocher

Discussion

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Member takes

Overview

May warrant sex-stratified early surveillance post-transplant; leaves open mechanisms of differential rejection and vasculopathy risks.

Structured PICO

Does female sex influence alloreactivity, acute rejection, transplant-related coronary artery disease, and survival in primary cardiac allograft recipients?

P
Population
520 consecutive recipients of a primary cardiac allograft between 1992 and 2000 at a single center
I
Intervention
Female sex
C
Comparator
Male sex
O
Outcome
Alloreactivity, acute rejection, transplant-related coronary artery disease, and survivalhard clinical

Female heart transplant recipients exhibit a higher risk of early allograft rejection and infection-related mortality, but a lower risk of late transplant-related coronary artery disease compared to males.

Cite This Study

Lietz et al. (2001) studied this question.

synapsesocial.com/papers/6a78872fd3a6aa87c6be4e9ahttps://doi.org/10.1161/circ.104.suppl_1.i-177
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of estrogen in cardiac transplantation: mechanistic insights and effects on clinical outcomes2026
  2. 2Sex Differences in Alloimmunity and Other Immunological Considerations in Organ Transplantation2026
  3. 3Estradiol enhances murine cardiac allograft rejection under cyclosporin and can be antagonized by the antiestrogen tamoxifen2002 · 28 citations
  4. 4HLA match and other immunological parameters in relation to survival, rejection severity, and accelerated coronary artery disease after heart transplant1990 · 15 citations
  5. 5Impact of biological sex on heart transplant patients admitted to cardiac rehabilitation: A 10-year retrospective cohort study2024 · 1 citations