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August 1, 2002Transplantation

Estradiol enhances murine cardiac allograft rejection under cyclosporin and can be antagonized by the antiestrogen tamoxifen

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Why the study?

Does tamoxifen or estradiol alter cardiac allograft survival in a murine model treated with cyclosporin?

Population

Murine cardiac allograft model using four gender combinations

Comparison

Tamoxifen, 17β-estradiol, and/or ovariectomy… vs Cyclosporin (CsA) alone

Design

Preclinical

Authors

YZYiping ZouWSWolfgang SteurerGKG nther Klima

Discussion

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Overview

Supports adjunctive tamoxifen in female murine cardiac allograft recipients on CsA; leaves open translation to clinical practice.

Structured PICO

Does tamoxifen or estradiol alter cardiac allograft survival in a murine model treated with cyclosporin?

P
Population
Murine cardiac allograft model (C57BL/10 donor hearts transplanted into C3H/He recipients) using four gender combinations
I
Intervention
Tamoxifen, 17β-estradiol, and/or ovariectomy added to cyclosporin (CsA)
C
Comparator
Cyclosporin (CsA) alone
O
Outcome
Allograft survivalhard clinical

Tamoxifen has a beneficial effect on heart allograft survival in female murine recipients treated with cyclosporin, counteracting the negative effects of estradiol on graft rejection.

Cite This Study

Zou et al. (2002) studied this question.

synapsesocial.com/papers/6a20f566920f77b2c049eccdhttps://doi.org/10.1097/00007890-200208150-00010
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of estrogen in cardiac transplantation: mechanistic insights and effects on clinical outcomes2026
  2. 2Increased Prevalence of Autoimmune Phenomena and Greater Risk for Alloreactivity in Female Heart Transplant Recipients2001 · 5 citations
  3. 3INHIBITION OF MYOINTIMAL HYPERPLASIA AND MACROPHAGE INFILTRATION BY ESTRADIOL IN AORTA ALLOGRAFTS1991 · 84 citations
  4. 4CARDIAC TRANSPLANTATION IN MICE I. FACTORS INFLUENCING THE TAKE AND SURVIVAL OF HETEROTOPIC GRAFTS1971 · 56 citations
  5. 5Inhibition of endothelin-1 improves survival and vasculopathy in rat cardiac transplants treated with cyclosporine2002 · 16 citations