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December 1, 1991Transplantation

Inhibition of Myointimal Hyperplasia and Macrophage Infiltration by Estradiol in Aorta Allografts

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Why the study?

Does estradiol treatment inhibit myointimal hyperplasia in aorta allografts in cholesterol-fed rabbits?

Population

Outbred New Zealand white male rabbits fed 0.5% cholesterol, undergoing aorta allograft transplantation and…

Comparison

Estradiol cypionate at 1, 10, 100, or 1000… vs Cottonseed oil (placebo) i.m. for 3 weeks

Design

Preclinical, Randomly assigned to one of five groups

Follow-up

3 weeks

Authors

LCLELAND P. CHENGMKMaki KuwaharaJJJeanette Jacobsson

Discussion

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Overview

May inhibit experimental allograft vasculopathy; hypothesis-generating and should not change clinical practice.

Structured PICO

Does estradiol treatment inhibit myointimal hyperplasia in aorta allografts in cholesterol-fed rabbits?

P
Population
Outbred New Zealand white male rabbits (2.7-3.5 kg, n=25) fed 0.5% cholesterol, undergoing aorta allograft transplantation and receiving cyclosporine (10 mg/kg/d s.c.)
I
Intervention
Estradiol cypionate at 1, 10, 100, or 1000 micrograms/kg/d i.m. for 3 weeks
C
Comparator
Cottonseed oil (placebo) i.m. for 3 weeks
O
Outcome
Degree of myointimal hyperplasia (area of myointimal thickening as a percent of total vessel area) and morphological changes evaluated by light and electron microscopy at 3 weekssurrogate

Estradiol treatment significantly inhibits myointimal hyperplasia and preserves endothelial cell ultrastructure in a rabbit model of aorta allograft atherosclerosis.

Cite This Study

CHENG et al. (1991) studied this question.

synapsesocial.com/papers/6a7746312e130d02afec7aachttps://doi.org/10.1097/00007890-199112000-00006
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Estrogen Treatment Inhibits Vascular Endothelial Senescence and Asymmetrical Dimethylarginine in Ovariectomized Rabbits2010 · 9 citations
  2. 2Estradiol enhances murine cardiac allograft rejection under cyclosporin and can be antagonized by the antiestrogen tamoxifen2002 · 28 citations
  3. 3Oestradiol Inhibition of Vascular Myointimal Proliferation Following Immune, Chemical and Mechanical Injury2007 · 12 citations
  4. 4Triple Drug Immunosuppression Significantly Reduces Aortic Allograft Arteriosclerosis in the Rat1996 · 25 citations
  5. 5Effects of estradiol on transcriptional profiles in atherosclerotic iliac arteries in ovariectomized cynomolgus macaques2013 · 5 citations