Why the study?
Does intracoronary hexachlorotetrafluorobutane induce reflex hemodynamic changes and ventricular fibrillation in non-thoracotomized dogs?
Population
Non-thoracotomized dogs
Comparison
Intracoronary administration of… vs Prereserpinized dogs, bilaterally vagotomized…
Design
Preclinical
Follow-up
up to 1 hour
Authors
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Intracoronary Hexa triggers vagally mediated VF in dogs; leaves open whether similar reflexes contribute to human ischemic arrhythmias.
Does intracoronary hexachlorotetrafluorobutane induce reflex hemodynamic changes and ventricular fibrillation in non-thoracotomized dogs?
Myocardial necrobiosis induced by hexachlorotetrafluorobutane triggers reflex inhibition of sympathetic activity and ventricular fibrillation, with the afferent pathway mediated via the vagus nerve.
Ascanio et al. (1965) studied this question.
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