Key result
Extracellular matrix coating on SIBS reduced bovine serum albumin (5.38 vs 90.84 μg/cm2) and fibrinogen (31.53 vs 132.38 μg/cm2) adsorption compared to the original material.
Why the study?
New-type polymer materials provide potential choices for prosthetic heart valves, but enhancing the biocompatibility of polystyrene-block-isobutylene-block-styrene (SIBS) is needed.
Does extracellular matrix coating improve the biocompatibility of SIBS polymer for prosthetic heart valves?
Does extracellular matrix coating improve the biocompatibility of SIBS polymer for prosthetic heart valves?
Extracellular matrix coating significantly improves the biocompatibility of SIBS polymer by reducing protein and platelet adsorption, highlighting its potential for prosthetic heart valve development.
Answers are grounded in this paper and cite their sources.
ECM coating may improve SIBS hemocompatibility for valves; leaves open need for in vivo and clinical validation.
Prosthetic heart valve replacement is an effective therapy for patients with valvular heart disease. New-type polymer materials provide potential choices of material for preparing prosthetic heart valves. In this study, we focused on enhancing the biocompatibility of polystyrene-block-isobutylene-block-styrene (SIBS) by surface modification with an extracellular matrix (ECM). Experimental results demonstrated that the ECM coating increased the adsorption resistance against protein and platelets. SIBS coated with an ECM adsorbed much less bovine serum albumin and fibrinogen (5.38 μg cm-2 and 31.53 μg cm-2, respectively) than the original material (90.84 μg cm-2 and 132.38 μg cm-2, respectively). The relative platelet adsorption of the ECM-modified SIBS was lower than that of SIBS (0.04 versus 0.10). Moreover, the surface coating could also reduce endothelial cytotoxicity, suppress the immune response, and potentially induce tissue regeneration. In conclusion, ECM coating improved the biocompatibility of SIBS effectively.
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Wu et al. (2020) studied Valvular heart disease. Extracellular matrix (ECM) coating on polystyrene-block-isobutylene-block-styrene (SIBS) vs. Original SIBS material was evaluated on Bovine serum albumin and fibrinogen adsorption. Extracellular matrix coating on SIBS reduced bovine serum albumin (5.38 vs 90.84 μg/cm2) and fibrinogen (31.53 vs 132.38 μg/cm2) adsorption compared to the original material.
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