Phospholipid modification of SIBS polymer significantly improves its hemocompatibility by reducing platelet adhesion, highlighting its potential utility in synthetic heart valves.
May support SIBS modification for valve biomaterials; animal data leave clinical translation open pending further studies.
Poly(styrene-block-isobutylene-block-styrene) ('SIBS') is selected for a novel tri-leaflet heart valve due to its high resistance to oxidation, hydrolysis, and enzyme attack. SIBS is modified using six different phospholipids and its mechanical properties characterized by tensile stress, peel strength, shear strength, contact angle, and surface energy, and then for hemocompatibility by studying the adhesion of fluorescently labeled platelets in a parallel plate chamber under physiological flow conditions. Phospholipid modification decreases SIBS tensile stress (at 45% strain) by 30% and reduces platelet adhesion by a factor of 10, thereby improving its hemocompatibility and its potential use as a synthetic heart valve.
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Duraiswamy et al. (2008) studied this question.
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