Analysis of Mechanisms for Increased Blood Pressure Variability in Rats Continuously Infused with Angiotensin II

Figures

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  Figure 1. Representative 24 h records of SBP of rats subcutaneously infused with angiotensin II with (b) or without (a) oral administration of azelnidipine over 14 days. SBP levels were measured every 15 min by a telemetry system for 24 hours before and after 7 and 14 days of the infusion.

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  Figure 2. Representative plots for relationships between systolic blood pressure (SBP) and heart rate (HR) monitored every 15 min during the light cycle of 12 hours before (a), 7 days (b), and 14 days (c) following continuous infusion of angiotensin II. N.S.; not significant.

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  Figure 3. Time course of correlation coefficient (r) for the relationships between systolic blood pressure (SBP) and heart rate (HR) during the light (a) and dark (b) cycles of 12 hours in control rats and those infused with angiotensin II (Ang II) with or without oral administration of azelnidipine (Azl). Mean ± S.E.; n = 8; ∗∗P < 0.01, vs. control; ++P < 0.01, vs. Ang II alone.

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  Figure 4. Changes in baroreceptor reflex sensitivities (BRSs) following the infusion of angiotensin II (Ang II) with or without oral administration of azelnidipine (Azl) over 14 days. Data shown are the differences between BRSs before and 7 or 14 days of the infusion (ΔBRSs). Mean ± S.E.; n = 8; ∗P < 0.05, vs. control; +P < 0.05, vs. Ang II alone.

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  Figure 5. Morphological analyses of sections of the aortic arch from control rats and those infused with angiotensin II (Ang II) with or without oral administration of azelnidipine (Azl) over 14 days. (a–c) Representative photos of hematoxylin eosin-stained aortic sections. (d–f) Quantitative analyses of medial and luminal area and media to lumen ratio. Mean ± S.E.; n = 8; ∗∗P < 0.01, vs. control; ++P < 0.01, vs. Ang II alone; bars, 1.0 mm.