Key result
Nifedipine CR (80 mg) showed an almost equal effect on 24-hour ambulatory blood pressure as amlodipine (10 mg) in patients with uncontrolled hypertension.
Why the study?
Does nifedipine controlled-release (80 mg) reduce 24-hr ambulatory blood pressure compared to amlodipine (10 mg) in uncontrolled hypertensives on background therapy?
RCT (n=51)
Open-label
randomly assigned
Yes
Does nifedipine controlled-release (80 mg) reduce 24-hr ambulatory blood pressure compared to amlodipine (10 mg) in uncontrolled hypertensives on background therapy?
High-dose nifedipine controlled-release and high-dose amlodipine provide comparable 24-hour ambulatory blood pressure reduction in patients with uncontrolled hypertension.
Supports equivalent ambulatory BP reduction with high-dose nifedipine CR versus amlodipine; leaves open optimal selection in broader refractory hypertension populations.
BACKGROUND: Data are sparse regarding ambulatory blood pressure (BP) reduction of up-titration from a standard dose to a high dose in both nifedipine controlled-release (CR) and amlodipine. This was a prospective, randomized, multicenter, open-label trial. PATIENTS AND METHODS: Fifty-one uncontrolled hypertensives medicated by two or more antihypertensive drugs including a renin-angiotensin system inhibitor and a calcium antagonist were randomly assigned to either the nifedipine CR (80 mg)/candesartan (8 mg) group or the amlodipine (10 mg)/candesartan (8 mg) group. RESULTS: The changes in 24-hr BP were comparable between the groups. The nifedipine group demonstrated a significant decrease in their urinary albumin creatinine ratio, whereas the amlodipine group demonstrated a significant decrease in their NTproBNP level. However, there was no significant difference in any biomarkers between the two groups. CONCLUSION: Nifedipine showed an almost equal effect on ambulatory blood pressure as amlodipine. Their potentially differential effects on renal protection and NTproBNP should be tested in larger samples.
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Mizuno et al. (2017) conducted an RCT in Uncontrolled hypertension (n=51). Nifedipine controlled-release (CR) and candesartan vs. Amlodipine 10 mg / candesartan 8 mg was evaluated on Changes in 24-hr BP. Nifedipine CR (80 mg) showed an almost equal effect on 24-hour ambulatory blood pressure as amlodipine (10 mg) in patients with uncontrolled hypertension.
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