Key result
Valproic acid infusion into the renal medulla increased stem cell markers, enhanced sodium excretion, and attenuated high salt-induced blood pressure increases in Dahl S rats.
Why the study?
Does valproic acid infusion into the renal medulla attenuate salt-sensitive hypertension in Dahl S rats?
Does valproic acid infusion into the renal medulla attenuate salt-sensitive hypertension in Dahl S rats?
Valproic acid infusion into the renal medulla activates stem cell function and attenuates salt-sensitive hypertension in a rat model.
Answers are grounded in this paper and cite their sources.
Should not yet change hypertension management; leaves open renal stem cell roles in salt-sensitive models.
BACKGROUND: Our previous study has detected a stem cell deficiency in the renal medulla in Dahl salt-sensitive (S) rats. This study determined whether infusion of valproic acid (VA), an agent known to stimulate the stem cell function, attenuated salt-sensitive hypertension in Dahl S rats. METHODS: Uninephrectomized Dahl S rats were infused with vehicle or VA (50mg/kg/d) into the renal medulla and fed with a low (LS) or high salt diet (HS). Stem cell marker and number were analyzed by immunohistochemistry, Real-time RT-PCR and Western blot. Sodium excretion and blood pressure were measured. RESULTS: VA significantly increased the mRNA and protein levels of FGF2, a stem cell niche factor, and CD133, a stem cell marker. The number of CD133+ cells was significantly increased in the renal medulla in VA-treated rats. Meanwhile, high salt-induced increases in the mRNA level of proinflammatory factors interleukin-1β and interleukin-6 were blocked in VA-treated rats. Functionally, sodium excretion in response to the blood pressure increase and acute sodium loading was significantly enhanced, sodium retention attenuated, high salt-induced increase of blood pressure reduced in VA-treated rats. CONCLUSION: Activation of stem cell function by VA inhibits the activation of proinflammatory factors and attenuates salt-sensitive hypertension in Dahl S rats.
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Wang et al. (2017) studied Salt-sensitive hypertension. Valproic acid (VA) vs. Vehicle was evaluated on Stem cell marker and number, sodium excretion, and blood pressure. Valproic acid infusion into the renal medulla increased stem cell markers, enhanced sodium excretion, and attenuated high salt-induced blood pressure increases in Dahl S rats.
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