Why the study?
Does streptomycin alter the changes in monophasic action potential duration induced by sustained stretch in guinea pig atria?
Population
16 guinea pig hearts perfused by the Langendorff method
Comparison
Slow onset but sustained stretch of the atrium… vs Sustained stretch of the atrium in the absence…
Design
Preclinical
Authors
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Guinea pig data do not support clinical targeting of stretch-activated channels; leaves open heterogeneous repolarization mechanisms in human atrial stretch.
Does streptomycin alter the changes in monophasic action potential duration induced by sustained stretch in guinea pig atria?
Sustained atrial stretch induces heterogeneous changes in action potential duration that are only partially mediated by stretch-activated channels blocked by streptomycin.
Babuty et al. (2001) studied this question.
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