August 12, 2006HeartOpen Access

Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins

View Full Paper

Ask AI

Bookmark

Why the study?

Does stretch increase the arrhythmogenic activity of pulmonary veins?

Population

Rabbit pulmonary veins (n=23)

Comparison

Stretch and perfusion with stretch-activated ion… vs Baseline (0 mg stretch)

Design

Preclinical

Authors

YCY.‐D. I. ChenNational Defense Medical Center YCYi–Ju ChenNational Yang Ming Chiao Tung University WWW WangcharoenNational Yang Ming Chiao Tung University

Discussion

Member takes

Implication

No immediate clinical implications for AF; leaves open stretch-activated channels as triggers in dilated pulmonary veins.

Structured PICO

Does stretch increase the arrhythmogenic activity of pulmonary veins?

Population

Rabbit pulmonary veins (n=23)

Intervention

Stretch (100 and 300 mg) and perfusion with stretch-activated ion channel blockers (gadolinium 1, 3, 10 µmol/l and streptomycin 10, 40 µmol/l)

Comparator

Baseline (0 mg stretch)

Outcome

Incidence of spontaneous activity, firing rates of spontaneous activity, and incidence of early and delayed post-depolarisationssurrogate

Stretch increases the arrhythmogenic activity of pulmonary veins via stretch-activated ion channels, providing a potential mechanism for the genesis of atrial fibrillation in dilated pulmonary veins.

Cite This Study

Chen et al. (2006) studied this question.

synapsesocial.com/papers/6a7eb77686f8ecc58a4f79d5 https://doi.org/10.1136/hrt.2006.089359

Topics

Atrial fibrillation Persistent AF management

View Full Paper

Ask AI

Bookmark

Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider