Effect of gadolinium on stretch‐induced changes in contraction and intracellularly recorded action‐ and afterpotentials of rat isolated atrium
Why the study?
Does gadolinium inhibit stretch-induced changes in action potentials and contraction force in rat isolated atria?
Population
Rat isolated atria
Comparison
Gadolinium (Gd3+) 80 microM vs Diltiazem (5.0 microM) or stretch alone
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports stretch-activated channel blockade in rat atria; leaves open translation to human arrhythmias.
Structured PICO
Does gadolinium inhibit stretch-induced changes in action potentials and contraction force in rat isolated atria?
P
Population
Rat isolated atria
I
Intervention
Gadolinium (Gd3+) 80 microM
C
Comparator
Diltiazem (5.0 microM) or stretch alone
O
Outcome
Stretch-induced changes in action potentials and contraction forcesurrogate
Gadolinium inhibits stretch-induced changes in cell electrophysiology and contraction in rat atrial cells by blocking stretch-activated ion channels.
Cite This Study
Tavi et al. (1996) studied this question.