Block of stretch‐activated atrial natriuretic peptide secretion by gadolinium in isolated rat atrium.
Population
Isolated superfused rat atrial preparations
Comparison
Gadolinium at 5, 20, or 80 microM; diltiazem at… vs Basal conditions without blockers
Design
Preclinical
Authors
Discussion
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Member takes
Implication
No immediate clinical implications; leaves open the role of stretch-activated channels in human ANP regulation.
Structured PICO
P
Population
Isolated superfused rat atrial preparations
I
Intervention
Gadolinium (GdCl3) at 5, 20, or 80 microM; diltiazem at 3 microM; NiCl2 at 50 microM
C
Comparator
Basal conditions without blockers
O
Outcome
Stretch-induced and basal atrial natriuretic peptide (ANP) secretion rates measured by radioimmunoassaysurrogate
Gadolinium blocks stretch-induced ANP secretion in isolated rat atria, suggesting the involvement of stretch-activated ion channels in ANP release.
Cite This Study
Laine et al. (1994) studied this question.