Key result
Gadolinium 50 micromol/L significantly increased the intra-atrial pressure threshold required to induce atrial fibrillation from 8.8 to 19.0 cm H2O (P<0.001).
Why the study?
Does gadolinium reduce stretch-induced vulnerability to atrial fibrillation in isolated rabbit hearts?
Does gadolinium reduce stretch-induced vulnerability to atrial fibrillation in isolated rabbit hearts?
Absolute Event Rate: 19% vs 8.8%
p-value: p=<0.001
Gadolinium, a stretch-activated channel blocker, dose-dependently reduces vulnerability to atrial fibrillation induced by acute atrial stretch in isolated rabbit hearts.
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Hypothesis-generating for stretch-activated channel blockade in AF; requires human studies before clinical consideration.
Bode et al. (2000) studied Atrial fibrillation (n=16). Gadolinium (Gd3+) vs. Baseline was evaluated on Intra-atrial pressure threshold to induce atrial fibrillation (cm H2O) (p=<0.001). Gadolinium 50 micromol/L significantly increased the intra-atrial pressure threshold required to induce atrial fibrillation from 8.8 to 19.0 cm H2O (P<0.001).
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