Key result
Gap junction enhancement with rotigaptide reduced sustained atrial fibrillation inducibility and shortened total conduction time, whereas block with carbenoxolone increased inducibility.
Why the study?
Does gap junction modulation affect stretch-induced atrial fibrillation vulnerability in isolated rabbit hearts?
Does gap junction modulation affect stretch-induced atrial fibrillation vulnerability in isolated rabbit hearts?
Gap junction modulators alter atrial fibrillation inducibility in an acute stretch model by affecting atrial conduction time rather than effective refractory period.
No takes yet. Share an insight, caveat, or question.
Gap junction modulation may alter stretch-induced AF vulnerability; hypothesis-generating and should not change practice.
Ueda et al. (2014) studied Atrial fibrillation. Rotigaptide (ZP123) and Carbenoxolone vs. Absence of gap junction enhancer or blocker was evaluated on Sustained AF (SAF) inducibility, effective refractory period (ERP), and total conduction time (TCT). Gap junction enhancement with rotigaptide reduced sustained atrial fibrillation inducibility and shortened total conduction time, whereas block with carbenoxolone increased inducibility.
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