Why the study?
Recent ex vivo evidence suggests pulsatile energy imparted from arteries to adjacent bundled veins increases venous flow, but this concept had not been tested in humans.
Does manipulating hydrostatic pressures affect flow in bundled versus nonbundled veins in humans?
Does manipulating hydrostatic pressures affect flow in bundled versus nonbundled veins in humans?
Provides in vivo evidence for a novel 'arterial pump' mechanism in humans where pulsatile energy from arteries preserves flow in adjacent bundled veins under high hydrostatic pressure.
May influence venous return models in bundled vessels; leaves open clinical relevance pending validation studies.
Venous return mechanisms have classically considered muscle and respiratory pumps; however, recent ex vivo evidence suggests that pulsatile energy imparted from arteries to adjacent bundled veins can increase venous flow under certain driving pressures. We tested this concept in humans by manipulating hydrostatic pressures and measuring flow in bundled and nonbundled veins. The bundled vein exhibited flow preservation at the highest hydrostatic pressure. We suggest a novel conservation of energy mechanism within the circulatory system.
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Cohen et al. (2023) studied this question.
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