Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma.

View Full Paper

Ask AI

Bookmark

Population

Seminal plasma and purified Prostate-specific antigen (PSA)

Design

Preclinical

Authors

Discussion

PSA-IGFBP-3 cleavage may alter IGF-I bioavailability in semen; leaves open relevance to prostate cancer or fertility.

Population

Seminal plasma and purified Prostate-specific antigen (PSA)

Intervention

Incubation with 125I-labeled human IGFBP-3

Outcome

IGFBP-3 protease activity and cleavage patternsurrogate

PSA acts as an IGFBP-3 protease in seminal plasma, potentially modulating IGF function in the reproductive system or prostate cancer.

Cohen et al. (1992) studied this question.

View Full Paper

Ask AI

Bookmark