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January 1, 2004Journal of Analytical ToxicologyOpen Access

A Rapid Procedure for the Monitoring of Amiodarone and N-Desethylamiodarone by HPLC-UV Detection

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Population

Serum or plasma samples for amiodarone monitoring

Design

Other

Authors

JJJoEtta M. JuenkeUniversity of UtahPBPaul I. BrownARUP Institute for Clinical and Experimental PathologyGMGwendolyn A. McMillinUniversity of Utah

Discussion

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Implication

May support amiodarone TDM in clinical labs; extends validated HPLC-UV methods for simultaneous DEA quantitation.

Structured PICO

P
Population
Serum or plasma samples for amiodarone monitoring
I
Intervention
Isocratic high-performance liquid chromatographic (HPLC) method with UV detection using Rocket column technology
O
Outcome
Simultaneous measurement and quantitation of amiodarone and N-desethylamiodarone (DEA)surrogate

A rapid HPLC-UV method allows for accurate and simultaneous monitoring of amiodarone and its active metabolite in serum or plasma, potentially improving patient safety.

Cite This Study

Juenke et al. (2004) studied this question.

synapsesocial.com/papers/6a79704314b028facf0dc5d6https://doi.org/10.1093/jat/28.1.63
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Also Consider

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  1. 1Development of an Enzyme-Linked Immunosorbent Assay for the Quantification of Amiodarone.2002 · 8 citations
  2. 2Amiodarone-Associated Pulmonary Toxicity: A Clinical and Pathologic Study of Eleven Cases1987 · 99 citations
  3. 3Influence of CYP3A Metabolizer Status on the Pharmacokinetics and Pharmacodynamics of Amiodarone2000 · 1 citations
  4. 4Dramatic inhibition of amiodarone metabolism induced by grapefruit juice2000 · 102 citations
  5. 5Therapeutic drug monitoring: antiarrhythmic drugs1998 · 114 citations