Key result
Tamoxifen was identified as the most acceptable alternative internal standard for amiodarone assay, yielding linear standard curves and low within-run (5.3%) and between-run (4.5%) CVs.
Population
Laboratory assay development for amiodarone and desethylamiodarone
Comparison
Tamoxifen as an internal standard for… vs L8040 and other potential alternative substances
Design
Other
Authors
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Supports uninterrupted amiodarone therapeutic drug monitoring; extends assay methods by validating tamoxifen as an accessible internal standard.
Systematic Review
Tamoxifen serves as an effective internal standard for the routine liquid chromatographic assay of amiodarone and its metabolite, replacing the no longer available L8040.
P. Timothy Pollak (1996) conducted a systematic review in Arrhythmias (Amiodarone assay development). Tamoxifen as an internal standard vs. L8040 and other alternatives was evaluated on Assay performance (linearity and coefficients of variation). Tamoxifen was identified as the most acceptable alternative internal standard for amiodarone assay, yielding linear standard curves and low within-run (5.3%) and between-run (4.5%) CVs.
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