Key result
Capillary electrophoresis correlates strongly with HPLC for amiodarone monitoring with under 10-minute run times.
Why the study?
Amiodarone requires routine serum level monitoring due to toxicity risk, but its hydrophobicity complicates analysis by HPLC and capillary electrophoresis.
Comparison
Capillary electrophoresis method vs high-performance liquid chromatography
Design
Analytical method development and comparison study
Authors
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May shorten lab turnaround for amiodarone monitoring; leaves open validation before replacing HPLC in practice.
Effect estimate: r=0.9
A simple capillary electrophoresis method for measuring amiodarone and its active metabolite provides rapid analysis (<10 min) that correlates well with standard HPLC methods.
Shihabi et al. (2005) studied Amiodarone toxicity monitoring. Capillary electrophoresis (CE) vs. HPLC was evaluated on Correlation between CE and HPLC for amiodarone measurement (r=0.9). Capillary electrophoresis compared well to HPLC for measuring amiodarone and its metabolite (r=0.9), with an analysis time of <10 minutes.
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