Key result
A newly developed enzyme-linked immunosorbent assay for amiodarone demonstrated high specificity and correlated strongly (r = 0.993) with HPLC measurements in human serum samples.
Population
2 white female rabbits for antibody production, 11 human serum samples, and human liver microsomes
Comparison
Enzyme-Linked Immunosorbent Assay for amiodarone… vs High-performance liquid chromatography (HPLC)
Design
Preclinical
Authors
Loading...
ELISA may simplify amiodarone TDM; leaves open need for clinical outcome validation before routine use.
Effect estimate: r = 0.993
A newly developed ELISA for amiodarone offers a sensitive and specific alternative to HPLC for therapeutic drug monitoring and pharmacokinetic studies.
Saita et al. (2002) studied this question. Enzyme-Linked Immunosorbent Assay (ELISA) vs. HPLC was evaluated on Correlation of amiodarone quantification between ELISA and HPLC (r = 0.993). A newly developed enzyme-linked immunosorbent assay for amiodarone demonstrated high specificity and correlated strongly (r = 0.993) with HPLC measurements in human serum samples.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: