Why the study?
Does cromolyn sodium improve cardiac remodeling and diastolic dysfunction in ovariectomized rats?
Population
Middle-aged, ovariectomized (OVX) female Fischer 344 × Brown Norway (F344BN) rats
Comparison
Cromolyn sodium administered subcutaneously by… vs Vehicle administered to ovariectomized rats, and…
Design
Preclinical
Follow-up
4 weeks of treatment (8 weeks post-ovariectomy)
Authors
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Mast cell stabilization may attenuate LVDD after estrogen loss in rats; leaves open clinical relevance in postmenopausal women.
Does cromolyn sodium improve cardiac remodeling and diastolic dysfunction in ovariectomized rats?
Mast cell inhibition with cromolyn attenuates left ventricular remodeling and diastolic dysfunction in a rat model of estrogen loss.
Wang et al. (2016) studied this question.
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