Key result
Ovariectomy in female rats with volume overload led to significant increases in mast cell density and collagen degradation compared to intact rats, which was abolished by nedocromil.
Female hormones appear to confer cardioprotection against volume overload-induced adverse remodeling by altering mast cell phenotype and preventing mast cell activation.
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May explain estrogen's role in limiting mast cell-driven remodeling; hypothesis-generating and not ready for clinical translation.
Lü et al. (2011) studied Ventricular volume overload. Aortocaval fistula (with or without ovariectomy and nedocromil) vs. Sham operation was evaluated on Myocardial mast cell density, collagen volume fraction, ET-1, SCF, and TNF-α. Ovariectomy in female rats with volume overload led to significant increases in mast cell density and collagen degradation compared to intact rats, which was abolished by nedocromil.
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