Why the study?
Does a shorter dosage interval (2, 3, and 4 months) compared to a longer interval (2, 4, and 6 months) affect the seroresponse to trivalent oral poliovirus vaccine in infants?
Population
108 infants
Comparison
Three doses of trivalent oral poliovirus vaccine… vs Three doses of trivalent oral poliovirus vaccine…
Design
RCT, randomly assigned
Follow-up
up to 6 months of age
Authors
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Shorter 2-3-4 month OPV intervals yield equivalent three-dose immunity; extends support for accelerated infant schedules in resource-limited settings.
Does a shorter dosage interval (2, 3, and 4 months) compared to a longer interval (2, 4, and 6 months) affect the seroresponse to trivalent oral poliovirus vaccine in infants?
A shorter dosage interval of 2, 3, and 4 months for the oral poliovirus vaccine provides virtually complete immunity comparable to a 2, 4, and 6-month interval in infants.
Cohen‐Abbo et al. (1995) studied this question.
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