Key result
Nicardipine was associated with improved infusion rate stability requiring fewer dose changes per hour (1.2 vs 1.7; P=0.004) compared to sodium nitroprusside, with no significant difference in costs.
Why the study?
Does nicardipine improve infusion rate stability and reduce postoperative costs compared to sodium nitroprusside in adults with postcardiac surgery hypertension?
Population
112 adults admitted to a cardiothoracic surgical intensive care unit after coronary artery bypass grafting…
Comparison
Nicardipine infusion (≥30 minutes) vs Sodium nitroprusside infusion (≥30 minutes)
Design
Cohort
Follow-up
postoperative period
Authors
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May favor nicardipine for infusion stability after cardiac surgery; leaves open randomized trials on outcomes.
Cohort (n=112)
No
Does nicardipine improve infusion rate stability and reduce postoperative costs compared to sodium nitroprusside in adults with postcardiac surgery hypertension?
Absolute Event Rate: 1.2% vs 1.7%
p-value: p=0.004
Nicardipine provides similar blood pressure control to sodium nitroprusside with improved infusion rate stability and no significant difference in postoperative costs in patients after cardiac surgery.
Barnes et al. (2012) conducted a cohort in Postoperative hypertension after cardiac surgery (n=112). Nicardipine vs. Sodium nitroprusside was evaluated on Infusion rate stability (dose changes per hour) (p=0.004). Nicardipine was associated with improved infusion rate stability requiring fewer dose changes per hour (1.2 vs 1.7; P=0.004) compared to sodium nitroprusside, with no significant difference in costs.