Key result
Intravenous nicardipine resulted in fewer dose adjustments per day compared to sodium nitroprusside (5.7 vs 8.8; P=0.0012) for hypertension control in patients with intracranial hemorrhage.
Why the study?
Does nicardipine improve blood pressure control and reduce dose adjustments compared to sodium nitroprusside in patients with subarachnoid or intracerebral hemorrhage?
Population
163 randomized patients with subarachnoid or intracerebral hemorrhage in the neurosurgical intensive care unit
Comparison
Nicardipine intravenous drip vs Sodium nitroprusside intravenous drip
Design
RCT, prospective randomized
Authors
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Simplifies acute hypertension management in intracranial hemorrhage; extends RCT support for nicardipine over nitroprusside.
RCT (n=163)
Does nicardipine improve blood pressure control and reduce dose adjustments compared to sodium nitroprusside in patients with subarachnoid or intracerebral hemorrhage?
Absolute Event Rate: 5.7% vs 8.8%
p-value: p=0.0012
Nicardipine is as effective as sodium nitroprusside for acute hypertension control in neurosurgical patients but requires fewer dose adjustments and additional medications.
Roitberg et al. (2008) conducted an RCT in Subarachnoid or intracerebral hemorrhage with hypertension (n=163). Nicardipine vs. Sodium nitroprusside was evaluated on Number of dose adjustments per patient day (p=0.0012). Intravenous nicardipine resulted in fewer dose adjustments per day compared to sodium nitroprusside (5.7 vs 8.8; P=0.0012) for hypertension control in patients with intracranial hemorrhage.
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