Key result
In a meta-analysis of 571 patients, sodium nitroprusside and nicardipine similarly reduced afterload after cardiac surgery, with nicardipine yielding a greater cardiac index.
Why the study?
Vasoactive medications are commonly used for afterload reduction and arterial hypertension after cardiac surgery, but the comparative effects of sodium nitroprusside and nicardipine on hemodynamics and cardiac performance needed determination.
Does nicardipine compared to sodium nitroprusside improve hemodynamics and cardiac performance in patients after cardiac surgery?
Population
571 patients after cardiac surgery across five studies
Comparison
Sodium nitroprusside vs nicardipine
Design
Systematic review and meta-analysis
Authors
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Either agent suitable for post-cardiac surgery afterload reduction; confirms hemodynamic equivalence in meta-analysis.
Meta-Analysis (n=571)
Does nicardipine compared to sodium nitroprusside improve hemodynamics and cardiac performance in patients after cardiac surgery?
Nicardipine and sodium nitroprusside provide similar afterload reduction after cardiac surgery, but nicardipine yields a greater cardiac index, making it potentially preferable for patients with low cardiac index.
Villarreal et al. (2020) conducted a meta-analysis in Arterial hypertension after cardiac surgery (n=571). Sodium nitroprusside vs. Nicardipine was evaluated on Hemodynamics and cardiac performance (blood pressure, heart rate, right atrial pressure, systemic vascular resistance, and stroke volume). In a meta-analysis of 571 patients, sodium nitroprusside and nicardipine similarly reduced afterload after cardiac surgery, with nicardipine yielding a greater cardiac index.
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