Key result
In a mouse model, HFpEF was associated with smaller white adipose tissue mass (epididymal AT 7.59 vs 10.67 mg/g) with increased beiging, and larger but dysfunctional brown adipose tissue.
Authors
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No immediate clinical implications; leaves open whether targeting adipose beiging or BAT improves HFpEF outcomes.
Valero‐Muñoz et al. (2016) studied Heart failure with preserved ejection fraction (HFpEF). HFpEF induction (d-aldosterone, uninephrectomy, 1% saline) vs. Sham operation was evaluated on Adipose tissue mass and beiging markers. In a mouse model, HFpEF was associated with smaller white adipose tissue mass (epididymal AT 7.59 vs 10.67 mg/g) with increased beiging, and larger but dysfunctional brown adipose tissue.
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