Key result
An intensive lifestyle intervention did not significantly reduce the risk of incident heart failure in overweight or obese adults with type 2 diabetes (HR 0.96; 95% CI 0.75-1.23).
Why the study?
The impact of a lifestyle intervention and changes in cardiorespiratory fitness and body mass index on the risk of heart failure in type 2 diabetes mellitus was not well established.
Does an intensive lifestyle intervention reduce the risk of incident heart failure in overweight or obese adults with type 2 diabetes mellitus?
RCT (n=5,109)
Does an intensive lifestyle intervention reduce the risk of incident heart failure in overweight or obese adults with type 2 diabetes mellitus?
Hazard Ratio: 0.96 (95% CI 0.75–1.23)
While an intensive lifestyle intervention did not reduce incident heart failure in overweight/obese adults with type 2 diabetes, higher baseline cardiorespiratory fitness and longitudinal improvements in fitness and weight were associated with lower heart failure risk, particularly HFpEF.
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Does not support intensive lifestyle intervention for HF prevention in overweight T2D; leaves open need for confirmatory RCTs.
Pandey et al. (2020) conducted an RCT in Overweight or obese adults with type 2 diabetes mellitus (n=5,109). Intensive lifestyle intervention vs. Diabetes support and education was evaluated on Incident heart failure (HR 0.96, 95% CI 0.75-1.23). An intensive lifestyle intervention did not significantly reduce the risk of incident heart failure in overweight or obese adults with type 2 diabetes (HR 0.96; 95% CI 0.75-1.23).
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