Key result
H2FPEF and HFA-PEFF step E scores yielded high positive (96.8% and 93.6%) and negative (95.5% and 98.3%) predictive values for HFpEF, but left 59.3% and 32.6% of patients in intermediate zones.
Why the study?
Clinical diagnosis of HFpEF remains challenging, prompting an evaluation of the diagnostic value of the H2FPEF score and HFA-PEFF step E score.
Do the H2FPEF score and HFA-PEFF step E score accurately diagnose HFpEF in hospitalised patients with shortness of breath or dyspnoea?
Observational (n=319)
Do the H2FPEF score and HFA-PEFF step E score accurately diagnose HFpEF in hospitalised patients with shortness of breath or dyspnoea?
Both H2FPEF and HFA-PEFF step E scores have high predictive values for HFpEF, but leave a significant proportion of patients in an intermediate category requiring further testing.
May aid HFpEF diagnosis in dyspneic inpatients; hypothesis-generating and requires prospective validation.
Background Clinical diagnosis of heart failure with preserved ejection fraction (HFpEF) remains challenging. The aim of the study is to evaluate the value of the H2FPEF score and HFA-PEFF step E score in the diagnosis of HFpEF.Methods 319 hospitalised patients with ‘shortness of breath’ or ‘dyspnoea’ were retrospectively collected and scored with the above two scores, respectively. They were divided into HFpEF group and non-HFpEF group in the study.Results Both the negative and positive predictive value of H2FPEF score and HFA-PEFF Step E score were 95.52%, 96.83% and 98.28%, 93.63%, respectively. However, there were 189 (59.25%) and 104 (32.60%) cases could not be diagnosed or excluded in the H2FPEF score and the HFA-PEFF step E score, respectively.Conclusions Both scores of the H2FPEF and the HFA-PEFF step E may be used to effectively rule out or confirm HFpEF according to the score point. However, there are three fifths and one third patients in the H2FPEF score and the HFA-PEFF step E score, respectively, in the intermediate scores who are needed further invasive catheterisation or exercise stress tests.
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Wang et al. (2023) conducted an observational in Heart failure with preserved ejection fraction (HFpEF) (n=319). H2FPEF score and HFA-PEFF step E score was evaluated on Negative and positive predictive value for HFpEF diagnosis. H2FPEF and HFA-PEFF step E scores yielded high positive (96.8% and 93.6%) and negative (95.5% and 98.3%) predictive values for HFpEF, but left 59.3% and 32.6% of patients in intermediate zones.
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