Key result
Metabolic syndrome did not reduce endothelial function, and a 24-week lifestyle modification program did not improve endothelial function in subjects with metabolic syndrome.
Why the study?
Does a 24-week lifestyle modification improve endothelial function in subjects with metabolic syndrome at increased risk for cardiovascular disease?
Cross-Sectional
Does a 24-week lifestyle modification improve endothelial function in subjects with metabolic syndrome at increased risk for cardiovascular disease?
Answers are grounded in this paper and cite their sources.
In subjects at increased cardiovascular risk, metabolic syndrome was not associated with reduced endothelial function, and a 24-week lifestyle modification improved metabolic parameters but not endothelial function.
We evaluated (1) endothelial function (FMD, ICAM-1 and VCAM-1) cross-sectionally in subjects with (MS+) and without (MS-) metabolic syndrome who were at increased risk for cardiovascular disease due to either HNBP and/or IGR, and (2) examined in a subgroup of subjects the effects of 24-week lifestyle modification on endothelial function. MS components, FMD by Doppler ultrasound, ICAM-1 and VCAM-1 by fasting blood samples were assessed. All of the endothelial functions were similar between MS- and MS+. Although waist circumference, blood pressure, and fasting glucose showed improvements, endothelial function remained unchanged following the intervention. The results showed that in our subject population, MS does not reduce endothelial function, and our 24-week lifestyle modification programme did not result in an improvement in endothelial function in MS+ despite the improvements in some MS components.
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Aizawa et al. (2009) conducted a cross-sectional in Metabolic syndrome. Metabolic syndrome and lifestyle modification vs. Subjects without metabolic syndrome was evaluated on Endothelial function (FMD, ICAM-1 and VCAM-1). Metabolic syndrome did not reduce endothelial function, and a 24-week lifestyle modification program did not improve endothelial function in subjects with metabolic syndrome.
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