Population
HeLa cell nuclear extracts and chimeric Drosophila doublesex (dsx) pre-mRNAs
Comparison
Various natural and synthetic polypurine sequences vs Sequences without polypurine stretches, poly…
Design
Preclinical
Authors
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Extends the catalog of exonic splicing enhancers; leaves open their impact on cardiac transcript variants in humans.
Polypurine sequences within downstream exons function as general splicing enhancers (ERS) that play an important role in splice site selection.
Tanaka et al. (1994) studied this question.