Effect of β-Blockers on Free Radical–Induced Cardiac Contractile Dysfunction
Why the study?
Do carvedilol and metoprolol prevent hydroxyl radical-induced contractile dysfunction in isolated human myocardium?
Population
Isolated human myocardium and myocardial membrane preparations
Comparison
Beta-receptor antagonists metoprolol… vs Hydroxyl radical exposure without beta-blocker…
Design
Preclinical
Authors
Discussion
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Member takes
Overview
No basis for preferring carvedilol clinically; leaves open SERCA-protective effects in oxidative stress models.
Structured PICO
Do carvedilol and metoprolol prevent hydroxyl radical-induced contractile dysfunction in isolated human myocardium?
P
Population
Isolated human myocardium (atrial and left ventricular myocardial preparations) and myocardial membrane preparations
I
Intervention
Beta-receptor antagonists metoprolol, carvedilol, and its metabolite BM-910228
C
Comparator
Hydroxyl radical (OH.) exposure without beta-blocker protection
O
Outcome
Isometric force of contraction, diastolic tension, and sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) activitysurrogate
Carvedilol and its metabolite BM-910228, but not metoprolol, protect human myocardium from hydroxyl radical-induced contractile dysfunction and SERCA inhibition.
Cite This Study
Flesch et al. (1999) studied this question.