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January 1, 1987Thrombosis and Haemostasis

The Platelet Volume Distribution: A Signature of the Prethrombotic State in Coronary Heart Disease?

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Why the study?

Is platelet volume distribution associated with acute myocardial infarction in patients presenting to a coronary care unit?

Population

175 consecutive patients in a coronary care unit, including 103 with acute myocardial infarction and 72 with…

Design

Cross-sectional

Authors

ETE. A. TrowbridgeUniversity of SheffieldJMJohn F. MartinHenry Smith Charity

Discussion

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Implication

Platelet volume distribution was associated with acute MI; leaves open its value as a biomarker or therapeutic target.

Structured PICO

Is platelet volume distribution associated with acute myocardial infarction in patients presenting to a coronary care unit?

P
Population
175 consecutive patients in a coronary care unit, including 103 with acute myocardial infarction and 72 with chest pain and ECG indications of myocardial ischaemia but no other clinical signs of acute MI.
C
Comparator
Patients with chest pain and ECG indications of myocardial ischaemia but no other clinical signs of acute myocardial infarction (n=72)
O
Outcome
Platelet parameters including count, mean platelet volume, volume dispersion, asymmetry, and convexitysurrogate

Large mean platelet volume and specific volume distributions may serve as a signature for a prethrombotic state in ischemic heart disease.

Cite This Study

Trowbridge et al. (1987) studied this question.

synapsesocial.com/papers/6a7a63cb77336a1bae02c738https://doi.org/10.1055/s-0038-1645979
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Significance of platelet volume indices and platelet count in ischaemic heart disease2009 · 95 citations
  2. 2Mean platelet volume and other platelet volume indices in patients with stable coronary artery disease and acute myocardial infarction: A case control study2012 · 104 citations
  3. 3Correlation of platelet count and platelet volume indices with coronary artery diseases2020 · 1 citations
  4. 4STUDY OF PLATELET VOLUME INDICES IN PATIENTS OF CORONARY ARTERY DISEASE2021
  5. 5Platelet Volume Indices and Platelet Count in Patients with Acute Coronary Syndrome – Case control study2016