Why the study?
Do catecholamines and alpha/beta receptor blockers alter right ventricular hemodynamics in a rat model?
Population
Female Sprague Dawley rats (n=32)
Comparison
Acute 20-minute infusion of noradrenaline or… vs Baseline measurements and single receptor…
Design
Preclinical
Follow-up
20 minutes
Authors
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Combined α/β blockade may blunt noradrenaline-induced RVSP rise in rats; leaves open translation to human RV failure.
Do catecholamines and alpha/beta receptor blockers alter right ventricular hemodynamics in a rat model?
In a rat model, combined alpha and beta receptor blockade is required to prevent noradrenaline-induced increases in right ventricular systolic pressure, as single receptor blockade is insufficient.
Irlbeck et al. (1993) studied this question.
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